CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.720 | Alkaline Phosphatase, subunit A | |
3.40.720.10 | Alkaline Phosphatase, subunit A |
Domain Context
CATH Clusters
Superfamily | Alkaline Phosphatase, subunit A |
Functional Family | Alkaline phosphatase |
Enzyme Information
3.1.3.1 |
Alkaline phosphatase.
based on mapping to UniProt P00634
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).
|
UniProtKB Entries (1)
P00634 |
PPB_ECOLI
Escherichia coli K-12
Alkaline phosphatase
|
PDB Structure
PDB | 3BDH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
To be Published
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