CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Glyoxylate/hydroxypyruvate reductase HPR3 |
Enzyme Information
| 1.1.1.237 |
Hydroxyphenylpyruvate reductase.
based on mapping to UniProt Q65CJ7
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)(+) = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H. (2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)(+) = 3-(3,4- dihydroxyphenyl)pyruvate + NAD(P)H.
-!- The enzyme participates in the biosynthesis of rosmarinic acid. -!- It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
|
UniProtKB Entries (1)
| Q65CJ7 |
HPPR_PLESU
Plectranthus scutellarioides
Hydroxyphenylpyruvate reductase
|
PDB Structure
| PDB | 3BA1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and substrate docking of a hydroxy(phenyl)pyruvate reductase from the higher plant Coleus blumei Benth.
Acta Crystallogr.,Sect.D
|
