CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Fidgetin-like 1

Enzyme Information

5.6.1.1
Microtubule-severing ATPase.
based on mapping to UniProt Q8I0P1
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
-!- A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome. -!- Formerly EC 3.6.4.3.

UniProtKB Entries (1)

Q8I0P1
SPAST_DROME
Drosophila melanogaster
Spastin

PDB Structure

PDB 3B9P
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
Roll-Mecak, A., Vale, R.D.
Nature