CATH Domain 3b8rA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P35968

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968

VGFR2_HUMAN

Homo sapiens

Vascular endothelial growth factor receptor 2

PDB Structure

PDB	3B8R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Trichoplusia
Primary Citation	Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors Weiss, M.M., Harmange, J.C., Polverino, A.J., Bauer, D., Berry, L., Berry, V., Borg, G., Bready, J., Chen, D., Choquette, D., Coxon, A., DeMelfi, T., Doerr, N., Estrada, J., Flynn, J., Graceffa, R.F., Harriman, S.P., Kaufman, S., La, D.S., Long, A., Neervannan, S., Patel, V.F., Potashman, M., Regal, K., Roveto, P.M., Schrag, M.L., Starnes, C., Tasker, A., Teffera, Y., Whittington, D.A., Zanon, R. J.Med.Chem.