CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.410 | Cholesterol Oxidase; domain 2 | |
3.30.410.10 | Cholesterol Oxidase; domain 2 |
Domain Context
CATH Clusters
Superfamily | Cholesterol Oxidase; domain 2 |
Functional Family |
Enzyme Information
5.3.3.1 |
Steroid Delta-isomerase.
based on mapping to UniProt P12676
A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.
|
1.1.3.6 |
Cholesterol oxidase.
based on mapping to UniProt P12676
Cholesterol + O(2) = cholest-5-en-3-one + H(2)O(2).
-!- Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyze the first two steps in the degradation of cholesterol. -!- The enzyme catalyzes the oxidation of the 3-beta-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Delta(5) position to the Delta(6) position (cf. EC 5.3.3.1).
|
UniProtKB Entries (1)
P12676 |
CHOD_STRS0
Streptomyces sp. SA-COO
Cholesterol oxidase
|
PDB Structure
PDB | 3B6D |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase
Protein Sci.
|