CATH Domain 3arnA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.40	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A
	2.70.40.10	Deoxyuridine triphosphatase (dUTPase)

Domain Context

CATH Clusters

Superfamily	2.70.40.10
Functional Family	Deoxyuridine triphosphatase

Enzyme Information

3.6.1.23

dUTP diphosphatase.

based on mapping to UniProt P33316

dUTP + H(2)O = dUMP + diphosphate.

UniProtKB Entries (1)

DUT_HUMAN

Homo sapiens

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

PDB Structure

PDB	3ARN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors Miyahara, S., Miyakoshi, H., Yokogawa, T., Chong, K.T., Taguchi, J., Muto, T., Endoh, K., Yano, W., Wakasa, T., Ueno, H., Takao, Y., Fujioka, A., Hashimoto, A., Itou, K., Yamamura, K., Nomura, M., Nagasawa, H., Shuto, S., Fukuoka, M. J.Med.Chem.