CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.1010
Functional Family

Enzyme Information

6.3.4.22
tRNA(Ile)(2)-agmatinylcytidine synthase.
based on mapping to UniProt O28025
ATP + agmatine + (tRNA(Ile)(2))-cytidine(34) + H(2)O = (tRNA(Ile)(2))-2- agmatinylcytidine(34) + AMP + 2 phosphate.
-!- The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNA(Ile)(2) at the oxo group in position 2 of cytidine(34). -!- This modification is crucial for accurate decoding of the genetic code. -!- In bacteria EC 6.3.4.19, catalyzes the modification of (tRNA(Ile)(2))-cytidine(34) to (tRNA(Ile)(2))-lysidine(34).

UniProtKB Entries (1)

O28025
TIAS_ARCFU
Archaeoglobus fulgidus DSM 4304
TRNA(Ile2) 2-agmatinylcytidine synthetase TiaS

PDB Structure

PDB 3AMU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of tRNA agmatinylation essential for AUA codon decoding
Osawa, T., Kimura, S., Terasaka, N., Inanaga, H., Suzuki, T., Numata, T.
Nat.Struct.Mol.Biol.
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