CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphorylase Kinase; domain 1 |
| Functional Family | Dual specificity mitogen-activated protein kinase kinase 4 |
Enzyme Information
| 2.7.12.2 |
Mitogen-activated protein kinase kinase.
based on mapping to UniProt P45985
ATP + a protein = ADP + a phosphoprotein.
-!- A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. -!- It is required for activation of EC 2.7.11.24. -!- Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
|
UniProtKB Entries (1)
| P45985 |
MP2K4_HUMAN
Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 4
|
PDB Structure
| PDB | 3ALN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state
Biochem.Biophys.Res.Commun.
|
