CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | cAMP-dependent protein kinase catalytic subunit |
Enzyme Information
2.7.11.11 |
cAMP-dependent protein kinase.
based on mapping to UniProt P00517
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
P00517 |
KAPCA_BOVIN
Bos taurus
CAMP-dependent protein kinase catalytic subunit alpha
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PDB Structure
PDB | 3AG9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol.
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