CATH Domain 3aefB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.20	Ubiquitin-like (UB roll)
	3.10.20.30	Beta-grasp domain

Domain Context

CATH Clusters

Superfamily	3.10.20.30
Functional Family	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Enzyme Information

1.3.5.1

Succinate dehydrogenase (quinone).

based on mapping to UniProt Q007T0

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

A5GZW8

DHSD_PIG

Sus scrofa

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

PDB Structure

PDB	3AEF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of porcine heart mitochondrial complex II with an empty quinone-binding pocket Harada, S., Sasaki, T., Shindo, M., Kido, Y., Inaoka, D.K., Omori, J., Osanai, A., Sakamoto, K., Mao, J., Matsuoka, S., Inoue, M., Honma, T., Tanaka, A., Kita, K. To be Published