CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.50 | 3-Layer(bba) Sandwich | |
3.50.50 | FAD/NAD(P)-binding domain | |
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
Superfamily | FAD/NAD(P)-binding domain |
Functional Family | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
Enzyme Information
1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q0QF01
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
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UniProtKB Entries (1)
A5GZW8 |
DHSD_PIG
Sus scrofa
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
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PDB Structure
PDB | 3AED |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-phenyl-benzamide
To be Published
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