CATH Domain 3aecA04

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.80	Rhinovirus 14, subunit 4
	4.10.80.40	succinate dehydrogenase protein domain

Domain Context

CATH Clusters

Superfamily	succinate dehydrogenase protein domain
Functional Family	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Enzyme Information

1.3.5.1

Succinate dehydrogenase (quinone).

based on mapping to UniProt Q0QF01

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q007T0

SDHB_PIG

Sus scrofa

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PDB Structure

PDB	3AEC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-(1-methylethyl)-benzamid Harada, S., Sasaki, T., Shindo, M., Kido, Y., Inaoka, D.K., Omori, J., Osanai, A., Sakamoto, K., Mao, J., Matsuoka, S., Inoue, M., Honma, T., Tanaka, A., Kita, K. To be Published