CATH Domain 3a3jA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.410	Peptidoglycan synthesis regulatory factor (PBP3), Domain 2
	2.60.410.10	D-Ala-D-Ala carboxypeptidase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	D-Ala-D-Ala carboxypeptidase, C-terminal domain
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt P44466

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

P44466

DACA_HAEIN

Haemophilus influenzae Rd KW20

D-alanyl-D-alanine carboxypeptidase DacA

PDB Structure

PDB	3A3J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae Kawai, F., Clarke, T.B., Roper, D.I., Han, G.-J., Hwang, K.Y., Unzai, S., Obayashi, E., Park, S.-Y., Tame, J.R.H. J.Mol.Biol.