CATH Domain 3a3dA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.80	D-tyrosyl-trna(Tyr) Deacylase; Chain: A;
	3.50.80.20	D-Ala-D-Ala carboxypeptidase C, peptidase S13

Domain Context

CATH Clusters

Superfamily	D-Ala-D-Ala carboxypeptidase C, peptidase S13
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt P45161

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt P45161

UniProtKB Entries (1)

P45161

DACB_HAEIN

Haemophilus influenzae Rd KW20

D-alanyl-D-alanine carboxypeptidase DacB

PDB Structure

PDB	3A3D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae Kawai, F., Clarke, T.B., Roper, D.I., Han, G.-J., Hwang, K.Y., Unzai, S., Obayashi, E., Park, S.-Y., Tame, J.R.H. J.Mol.Biol.