CATH Domain 2zzmA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.300	GMP Synthetase; Chain A, domain 3
	3.30.300.110	Met-10+ protein-like domains

Domain Context

CATH Clusters

Superfamily	Met-10+ protein-like domains
Functional Family	tRNA (guanine(37)-N1)-methyltransferase

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt Q58293

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q58293

TRM5B_METJA

Methanocaldococcus jannaschii DSM 2661

TRNA (guanine(37)-N1)-methyltransferase Trm5b

PDB Structure

PDB	2ZZM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation Goto-Ito, S., Ito, T., Kuratani, M., Bessho, Y., Yokoyama, S. Nat.Struct.Mol.Biol.