CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Thioredoxin reductase 1, cytoplasmic |
Enzyme Information
| 1.8.1.9 |
Thioredoxin-disulfide reductase.
based on mapping to UniProt Q16881
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.
|
UniProtKB Entries (1)
| Q16881 |
TRXR1_HUMAN
Homo sapiens
Thioredoxin reductase 1, cytoplasmic
|
PDB Structure
| PDB | 2ZZB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1.
J.Inorg.Biochem.
|