CATH Domain 2zu2A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.22.-

Cysteine endopeptidases.

based on mapping to UniProt P0C6U2

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt P0C6U2

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P0C6U2

R1A_CVH22

Human coronavirus 229E

Replicase polyprotein 1a

PDB Structure

PDB	2ZU2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds Lee, C.C., Kuo, C.J., Ko, T.P., Hsu, M.F., Tsui, Y.C., Chang, S.C., Yang, S., Chen, S.J., Chen, H.C., Hsu, M.C., Shih, S.R., Liang, P.H., Wang, A.H.-J. J.Biol.Chem.