1 keywords

CATH Domain 2zmmA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.190 Protein-Tyrosine Phosphatase; Chain A
Homologous Superfamily 3.90.190.10 Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 2ZMM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Wan, Z.-K., Lee, J., Hotchandani, R., Moretto, A., Binnun, E., Wilson, D.P., Kirincich, S.J., Follows, B.C., Ipek, M., Xu, W., Joseph-McCarthy, D., Zhang, Y.-L., Tam, M., Erbe, D.V., Tobin, J.F., Li, W., Tam, S.Y., Mansour, T.S., Wu, J.
Chemmedchem