CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.450 | Beta-Lactamase |
|
3.30.450.40 | GAF domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.450.40 |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.17 |
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9Y233
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
|
| 3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9Y233
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
|
UniProtKB Entries (1)
| Q9Y233 |
PDE10_HUMAN
Homo sapiens
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
|
PDB Structure
| PDB | 2ZMF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP
J.Biol.Chem.
|
