CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.10 | Thrombin, subunit H |
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2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Prothrombin |
Enzyme Information
3.4.21.5 |
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (2)
P00734 |
THRB_HUMAN
Homo sapiens
Prothrombin
|
P09945 |
HIRV2_HIRME
Hirudo medicinalis
Hirudin variant-2
|
PDB Structure
PDB | 2ZG0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Exploring thrombin S3 pocket
To be Published
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