CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cytochrome P450 monooxygenase

Enzyme Information

1.14.15.22
Vitamin D 1,25-hydroxylase.
based on mapping to UniProt P18326
(1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.
-!- An enzyme found in the bacterium Streptomyces griseolus. -!- Cf. EC 1.14.14.24 and EC 1.14.15.18.

UniProtKB Entries (1)

P18326
CPXE_STRGO
Streptomyces griseolus
Vitamin D3 dihydroxylase

PDB Structure

PDB 2ZBX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3
Sugimoto, H., Shinkyo, R., Hayashi, K., Yoneda, S., Yamada, M., Kamakura, M., Ikushiro, S., Shiro, Y., Sakaki, T.
Biochemistry