CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.630 | Cytochrome p450 | |
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450 |
Functional Family | Cytochrome P450 monooxygenase |
Enzyme Information
1.14.15.22 |
Vitamin D 1,25-hydroxylase.
based on mapping to UniProt P18326
(1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.
-!- An enzyme found in the bacterium Streptomyces griseolus. -!- Cf. EC 1.14.14.24 and EC 1.14.15.18.
|
UniProtKB Entries (1)
P18326 |
CPXE_STRGO
Streptomyces griseolus
Vitamin D3 dihydroxylase
|
PDB Structure
PDB | 2ZBX |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3
Biochemistry
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