CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Prostaglandin reductase 2 |
Enzyme Information
| 1.3.1.48 |
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q8N8N7
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).
|
UniProtKB Entries (1)
| Q8N8N7 |
PTGR2_HUMAN
Homo sapiens
Prostaglandin reductase 2
|
PDB Structure
| PDB | 2ZB8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2.
Structure
|