CATH Domain 2z50A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Geranylgeranyl pyrophosphate synthase

Enzyme Information

2.5.1.-	Transferring alkyl or aryl groups, other than methyl groups. based on mapping to UniProt Q12051
2.5.1.10	(2E,6E)-farnesyl diphosphate synthase. based on mapping to UniProt Q12051 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate. -!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
2.5.1.29	Geranylgeranyl diphosphate synthase. based on mapping to UniProt Q12051 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. -!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
2.5.1.1	Dimethylallyltranstransferase. based on mapping to UniProt Q12051 Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. -!- Will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

GGPPS_YEAST

Saccharomyces cerevisiae S288C

Geranylgeranyl pyrophosphate synthase

PDB Structure

PDB	2Z50
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation Chen, C.K.-M., Hudock, M.P., Zhang, Y., Guo, R.-T., Cao, R., No, J.H., Liang, P.-H., Ko, T.-P., Chang, T.-H., Chang, S.-C., Song, Y., Axelson, J., Kumar, A., Wang, A.H.-J., Oldfield, E. J.Med.Chem.