CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.2570 | Elongation factor 4, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Elongation factor 4, C-terminal domain |
| Functional Family | Translation factor GUF1, mitochondrial |
Enzyme Information
| 3.6.5.n1 |
Elongation factor 4.
based on mapping to UniProt O67618
GTP + H(2)O = GDP + phosphate.
-!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner.
|
UniProtKB Entries (1)
| O67618 |
LEPA_AQUAE
Aquifex aeolicus VF5
Elongation factor 4
|
PDB Structure
| PDB | 2YWE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of GTP-binding protein LepA from Aquifex aeolicus
To be Published
|
