CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | tRNA (guanine(26)-N(2))-dimethyltransferase |
Enzyme Information
| 2.1.1.216 |
tRNA (guanine(26)-N(2))-dimethyltransferase.
based on mapping to UniProt O59493
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L- homocysteine + N(2)-dimethylguanine(26) in tRNA.
-!- The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions. -!- In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA. -!- Formerly EC 2.1.1.32.
|
UniProtKB Entries (1)
| O59493 |
TRM1_PYRHO
Pyrococcus horikoshii OT3
TRNA (guanine(26)-N(2))-dimethyltransferase
|
PDB Structure
| PDB | 2YTZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii
J.Mol.Biol.
|