CATH Domain 2ypeA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1740	2',3'-cyclic nucleotide 3'-phosphodiesterase fold
	3.90.1740.10	2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily

Domain Context

CATH Clusters

Superfamily	2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily
Functional Family	Tetratricopeptide repeat protein 25

Enzyme Information

3.1.4.37

2',3'-cyclic-nucleotide 3'-phosphodiesterase.

based on mapping to UniProt P16330

Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 2'-phosphate.

-!- The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. -!- An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyzes the corresponding 3',5'-cyclic phosphates, more slowly. -!- This latter enzyme has been called cyclic-CMP phosphodiesterase.

UniProtKB Entries (1)

P16330

CN37_MOUSE

Mus musculus

2',3'-cyclic-nucleotide 3'-phosphodiesterase

PDB Structure

PDB	2YPE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, I., Kursula, P. J.Mol.Biol.