CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Ephrin type-B receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54760
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54760
EPHB4_HUMAN
Homo sapiens
Ephrin type-B receptor 4

PDB Structure

PDB 2YN8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Stability and Solubility Engineering of the Ephb4 Tyrosine Kinase Catalytic Domain Using a Rationally Designed Synthetic Library.
Overman, R.C., Green, I., Truman, C.M., Read, J.A., Embrey, K.J., Mcalister, M.S.B., Attwood, T.K.
Protein Eng.Des.Sel.