CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family |
Enzyme Information
| 1.14.13.92 |
Phenylacetone monooxygenase.
based on mapping to UniProt Q47PU3
Phenylacetone + NADPH + O(2) = benzyl acetate + NADP(+) + H(2)O.
-!- NADH cannot replace NADPH as coenzyme. -!- In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones (1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan- 2-one and 3-phenylbutan-2-one), some alipatic ketones (e.g. dodecan- 2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).
|
UniProtKB Entries (1)
| Q47PU3 |
PAMO_THEFY
Thermobifida fusca YX
Phenylacetone monooxygenase
|
PDB Structure
| PDB | 2YLR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Snapshots of Enzymatic Baeyer-Villiger Catalysis: Oxygen Activation and Intermediate Stabilization.
J.Biol.Chem.
|
