CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.102 | 3-layer Sandwich |
|
2.102.10 | Rieske Iron-sulfur Protein |
|
2.102.10.10 | Rieske [2Fe-2S] iron-sulphur domain |
Domain Context
CATH Clusters
| Superfamily | Rieske [2Fe-2S] iron-sulphur domain |
| Functional Family |
Enzyme Information
| 1.14.12.18 |
Biphenyl 2,3-dioxygenase.
based on mapping to UniProt P37333
Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
-!- The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center. -!- Chlorine-substituted biphenyls can also act as substrates. -!- Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
|
UniProtKB Entries (1)
| P37334 |
BPHE_PARXL
Paraburkholderia xenovorans LB400
Biphenyl dioxygenase subunit beta
|
PDB Structure
| PDB | 2YFI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Retuning Rieske-Type Oxygenases to Expand Substrate Range.
J.Biol.Chem.
|
