CATH Classification

Domain Context

CATH Clusters

Superfamily Kinase associated domain 1, KA1
Functional Family

Enzyme Information

2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt P54645
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
2.7.11.31
[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
based on mapping to UniProt P54645
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.
-!- Activated by AMP. -!- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein. -!- Histones can also act as acceptors. -!- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79. -!- Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. -!- GTP can act instead of ATP. -!- Formerly EC 2.7.1.109.
2.7.11.27
[Acetyl-CoA carboxylase] kinase.
based on mapping to UniProt P54645
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
-!- Phosphorylates and inactivates EC 6.4.1.2, which can be dephosphorylated and reactivated by EC 3.1.3.17. -!- More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form. -!- Phosphorylates serine residues. -!- Formerly EC 2.7.1.111 and EC 2.7.1.128.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P54645
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (2)

P54645
AAPK1_RAT
Rattus norvegicus
5'-AMP-activated protein kinase catalytic subunit alpha-1
O43741
AAKB2_HUMAN
Homo sapiens
5'-AMP-activated protein kinase subunit beta-2

PDB Structure

PDB 2Y8L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Mammalian Ampk and its Regulation by Adp
Xiao, B., Sanders, M.J., Underwood, E., Heath, R., Mayer, F., Carmena, D., Jing, C., Walker, P.A., Eccleston, J.F., Haire, L.F., Saiu, P., Howell, S.A., Aasland, R., Martin, S.R., Carling, D., Gamblin, S.J.
Nature