CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity mitogen-activated protein kinase kinase 1

Enzyme Information

2.7.12.2
Mitogen-activated protein kinase kinase.
based on mapping to UniProt P29678
ATP + a protein = ADP + a phosphoprotein.
-!- A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. -!- It is required for activation of EC 2.7.11.24. -!- Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.

UniProtKB Entries (2)

P29678
MP2K1_RABIT
Oryctolagus cuniculus
Dual specificity mitogen-activated protein kinase kinase 1
Q6VAB6
KSR2_HUMAN
Homo sapiens
Kinase suppressor of Ras 2

PDB Structure

PDB 2Y4I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek
Brennan, D.F., Dar, A.C., Hertz, N.T., Chao, W., Burlingame, A.L., Shokat, K.M., Barford, D.
Nature