CATH Domain 2y33A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.620	q2cbj1_9rhob like domain

Domain Context

CATH Clusters

Superfamily	q2cbj1_9rhob like domain
Functional Family	Egl nine homolog 1

Enzyme Information

1.14.11.29

Hypoxia-inducible factor-proline dioxygenase.

based on mapping to UniProt Q9GZT9

Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).

-!- Contains iron, and requires ascorbate. -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. -!- The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

UniProtKB Entries (1)

Q9GZT9

EGLN1_HUMAN

Homo sapiens

Egl nine homolog 1

PDB Structure

PDB	2Y33
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) Chowdhury, R., Flashman, E., Mecinovic, J., Kramer, H.B., Kessler, B.M., Frapart, Y.M., Boucher, J.-L., Clifton, I.J., McDonough, M.A., Schofield, C.J. J.Mol.Biol.