CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.20 | Dihydropteroate synthase-like |
Domain Context
CATH Clusters
| Superfamily | Dihydropteroate synthase-like |
| Functional Family |
Enzyme Information
| 1.17.7.3 |
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
based on mapping to UniProt Q72H18
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.
-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).
|
UniProtKB Entries (1)
| Q72H18 |
ISPG_THET2
Thermus thermophilus HB27
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
|
PDB Structure
| PDB | 2Y0F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the E-1-Hydroxy-2-Methyl-But-2-Enyl-4-Diphosphate Synthase (Gcpe) from Thermus Thermophilus.
FEBS Lett.
|