CATH Domain 2xyuA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Ephrin type-A receptor 5

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q03137

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q03137

EPHA4_MOUSE

Mus musculus

Ephrin type-A receptor 4

PDB Structure

PDB	2XYU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment Based Lead Discovery of Small Molecule Inhibitors for the Epha4 Receptor Tyrosine Kinase. Van Linden, O.P., Farenc, C.J.A., Zoutman, W.H., Hameetman, L., Wijtmans, M., Leurs, R., Tensen, C.P., Siegal, G., De Esch, I.J. Eur.J.Med.Chem.