CATH Domain 2xrfB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1580	Nucleoside phosphorylase domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase domain
Functional Family	Uridine phosphorylase 2

Enzyme Information

2.4.2.3

Uridine phosphorylase.

based on mapping to UniProt O95045

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

-!- The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. -!- The mammalian enzyme also accepts 2'-deoxyuridine. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

O95045

UPP2_HUMAN

Homo sapiens

Uridine phosphorylase 2

PDB Structure

PDB	2XRF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Uridine Phosphorylase 2 Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Der Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P. To be Published