CATH Classification
Domain Context
CATH Clusters
| Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
| Functional Family | Bifunctional IPC transferase and DIPP synthase |
Enzyme Information
| 2.7.8.34 |
CDP-L-myo-inositol myo-inositolphosphotransferase.
based on mapping to UniProt O29976
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo- inositol) 3,1'-phosphate 1-phosphate.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP- 1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3- phosphate, a widespread organic solute in microorganisms adapted to hot environments.
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| 2.7.7.74 |
1L-myo-inositol 1-phosphate cytidylyltransferase.
based on mapping to UniProt O29976
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments. -!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 is absolutely specific for CTP and 1L-myo- inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
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UniProtKB Entries (1)
| O29976 |
DIPPS_ARCFU
Archaeoglobus fulgidus DSM 4304
Bifunctional IPC transferase and DIPP synthase
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PDB Structure
| PDB | 2XMH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles.
J. Bacteriol.
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