CATH Domain 2xk1C02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.80	D-tyrosyl-trna(Tyr) Deacylase; Chain: A;
	3.50.80.20	D-Ala-D-Ala carboxypeptidase C, peptidase S13

Domain Context

CATH Clusters

Superfamily	D-Ala-D-Ala carboxypeptidase C, peptidase S13
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt P39045

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

P39045

DAC_ACTSP

Actinomadura sp. R39

D-alanyl-D-alanine carboxypeptidase

PDB Structure

PDB	2XK1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors Woon, E.C.Y., Zervosen, A., Sauvage, E., Simmons, K.J., Ivec, M., Inglis, S.R., Fishwick, C.W.G., Gobec, S., Charlier, P., Luxen, A., Schofield, C.J. Acs Med.Chem.Lett.