CATH Domain 2xh1A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt Q8N5Z0 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39	2-aminoadipate transaminase. based on mapping to UniProt Q8N5Z0 L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

AADAT_HUMAN

Homo sapiens

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB	2XH1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure-Based Selective Targeting of the Pyridoxal 5'-Phsosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement Rossi, F., Casazza, V., Garavaglia, S., Sathyasaikumar, K.V., Schwarcz, R., Kojima, S.I., Okuwaki, K., Ono, S.I., Kajii, Y., Rizzi, M. J.Med.Chem.