CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family D-erythrose-4-phosphate dehydrogenase

Enzyme Information

1.2.1.72
Erythrose-4-phosphate dehydrogenase.
based on mapping to UniProt P0A9B6
D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH.
-!- Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate. -!- Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.

UniProtKB Entries (1)

P0A9B6
E4PD_ECOLI
Escherichia coli K-12
D-erythrose-4-phosphate dehydrogenase

PDB Structure

PDB 2XF8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Characterization of Erythrose-4- Phosphate Dehydrogenase from Escherichia Coli: Peculiar Features When Compared to Phosphorylating Gapdhs
Moniot, S., Didierjean, C., Boschi-Muller, S., Branlant, G., Corbier, C.
To be Published