CATH Domain 2xcyA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.10

Domain Context

CATH Clusters

Superfamily	2.120.10.10
Functional Family	Exo-alpha-sialidase

Enzyme Information

3.2.1.18

Exo-alpha-sialidase.

based on mapping to UniProt Q4WQS0

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q4WQS0

SIA_ASPFU

Aspergillus fumigatus Af293

Exo-alpha-sialidase

PDB Structure

PDB	2XCY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights. Telford, J.C., Yeung, J.H., Xu, G., Kiefel, M.J., Watts, A.G., Hader, S., Chan, J., Bennet, A.J., Moore, M.M., Taylor, G.L. J.Biol.Chem.