CATH Domain 2xcoA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1360	Gyrase A; domain 2
	3.30.1360.40

Domain Context

CATH Clusters

Superfamily	3.30.1360.40
Functional Family	DNA gyrase subunit A

Enzyme Information

5.6.2.3	DNA topoisomerase (ATP-hydrolyzing). based on mapping to UniProt P66937 ATP-dependent breakage, passage and rejoining of double-stranded DNA. -!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
5.6.2.3	DNA topoisomerase (ATP-hydrolyzing). based on mapping to UniProt Q99XG5 ATP-dependent breakage, passage and rejoining of double-stranded DNA. -!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

GYRB_STAAN

Staphylococcus aureus subsp. aureus N315

DNA gyrase subunit B

PDB Structure

PDB	2XCO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents. Bax, B.D., Chan, P.F., Eggleston, D.S., Fosberry, A., Gentry, D.R., Gorrec, F., Giordano, I., Hann, M.M., Hennessy, A., Hibbs, M., Huang, J., Jones, E., Jones, J., Brown, K.K., Lewis, C.J., May, E.W., Saunders, M.R., Singh, O., Spitzfaden, C., Shen, C., Shillings, A., Theobald, A.F., Wohlkonig, A., Pearson, N.D., Gwynn, M.N. Nature