CATH Domain 2x5oA03

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.20	Mur ligase, C-terminal domain

Superfamily	Mur ligase, C-terminal domain
Functional Family	UDP-N-acetylmuramoylalanine--D-glutamate ligase

6.3.2.9

UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.

based on mapping to UniProt P14900

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.

-!- Involved in the synthesis of a cell-wall peptide in bacteria.

MURD_ECOLI

Escherichia coli K-12

UDP-N-acetylmuramoylalanine--D-glutamate ligase

PDB	2X5O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase. Zidar, N., Tomasic, T., Sink, R., Rupnik, V., Kovac, A., Turk, S., Patin, D., Blanot, D., Contreras Martel, C., Dessen, A., Muller Premru, M., Zega, A., Gobec, S., Peterlin Masic, L., Kikelj, D. J. Med. Chem.