CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
Enzyme Information
| 6.3.2.9 |
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
based on mapping to UniProt P14900
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.
-!- Involved in the synthesis of a cell-wall peptide in bacteria.
|
UniProtKB Entries (1)
| P14900 |
MURD_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoylalanine--D-glutamate ligase
|
PDB Structure
| PDB | 2X5O |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.
J. Med. Chem.
|
