CATH Domain 2x4zA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O96013

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O96013

PAK4_HUMAN

Homo sapiens

Serine/threonine-protein kinase PAK 4

PDB Structure

PDB	2X4Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-Molecule P21-Activated Kinase Inhibitor Pf- 3758309 is a Potent Inhibitor of Oncogenic Signaling and Tumor Growth. Murray, B., Guo, C., Piraino, J., Westwick, J., Zhang, C., Lamerdin, J., Dagostino, E., Knighton, D.R., Loi, C.-M., Zager, M., Kraynov, E., Popoff, I., Christensen, J., Martinez, R., Kephart, S., Marakovits, J., Karlicek, S., Bergqvist, S., Smeal, T. Proc.Natl.Acad.Sci.USA