CATH Domain 2x0jA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.37

Malate dehydrogenase.

based on mapping to UniProt O08349

(S)-malate + NAD(+) = oxaloacetate + NADH.

-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

MDH_ARCFU

Archaeoglobus fulgidus DSM 4304

Malate dehydrogenase

PDB Structure

PDB	2X0J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The 2.9A Resolution Crystal Structure of Malate Dehydrogenase from Archaeoglobus Fulgidus: Mechanisms of Oligomerisation and Thermal Stabilisation. Irimia, A., Vellieux, F.M.D., Madern, D., Zaccai, G., Karshikoff, A., Tibbelin, G., Ladenstein, R., Lien, T., Birkeland, N.K. J.Mol.Biol.