CATH Domain 2x05A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Exo-beta-D-glucosaminidase

Enzyme Information

3.2.1.165

Exo-1,4-beta-D-glucosaminidase.

based on mapping to UniProt Q56F26

Hydrolysis of chitosan or chitosan oligosaccharides to remove successive D-glucosamine residues from the non-reducing termini.

-!- Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi and comprises D-glucosamine residues with a variable content of GlcNAc residues. -!- Acts specifically on chitooligosaccharides and chitosan, having maximal activity on chitotetraose, chitopentaose and their corresponding alcohols. -!- Can degrade GlcN-GlcNAc but not GlcNAc-GlcNAc.

UniProtKB Entries (1)

Q56F26

EBDG_AMYOR

Amycolatopsis orientalis

Exo-beta-D-glucosaminidase

PDB Structure

PDB	2X05
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of the Exo-Beta-D-Glucosaminidase Csxa by a Glucosamine-Configured Castanospermine and an Amino-Australine Analogue. Pluvinage, B., Ghinet, M.G., Brzezinski, R., Boraston, A.B., Stubbs, K.A. Org.Biomol.Chem.