CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O08679
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt O08679
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

O08679
MARK2_RAT
Rattus norvegicus
Serine/threonine-protein kinase MARK2

PDB Structure

PDB 2WZJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Function of Polarity-Inducing Kinase Family Mark/Par-1 within the Branch of Ampk/Snf1-Related Kinases.
Marx, A., Nugoor, C., Panneerselvam, S., Mandelkow, E.
Faseb J.