1 keywords

CATH Domain 2wwjA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.650 Cupin

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family Lysine-specific demethylase 4A

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164

UniProtKB Entries (1)

O75164
KDM4A_HUMAN
Homo sapiens
Lysine-specific demethylase 4A

PDB Structure

PDB 2WWJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
Rose, N.R., Woon, E.C., Kingham, G.L., King, O.N., Mecinovic, J., Clifton, I.J., Ng, S.S., Talib-Hardy, J., Oppermann, U., McDonough, M.A., Schofield, C.J.
J. Med. Chem.