CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.1440 | GIY-YIG endonuclease |
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3.40.1440.40 |
Domain Context
CATH Clusters
Superfamily | 3.40.1440.40 |
Functional Family |
Enzyme Information
3.1.21.8 |
T(4) deoxyribonuclease II.
based on mapping to UniProt P07059
Endonucleolytic nicking and cleavage of cytosine-containing double- stranded DNA.
-!- This phage T(4) enzyme is involved in degradation of host DNA. -!- The enzyme primarily catalyzes nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. -!- Double-stranded breaks are produced 5- to 10-fold less frequently. -!- It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine.
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UniProtKB Entries (1)
P07059 |
END2_BPT4
Escherichia virus T4
Endonuclease II
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PDB Structure
PDB | 2WSH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of Bacteriophage T4 Endonuclease II Mutant E118A, a Tetrameric Giy-Yig Enzyme.
J.Mol.Biol.
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