1 keywords

CATH Domain 2wo8C00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.390 Collagenase (Catalytic Domain)
Homologous Superfamily 3.40.390.10 Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 2WO8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors.
Holmes, I.P., Gaines, S., Watson, S.P., Lorthioir, O., Walker, A., Baddeley, S.J., Herbert, S., Egan, D., Convery, M.A., Singh, O.M.P., Gross, J.W., Strelow, J.M., Smith, R.H., Amour, A.J., Brown, D., Martin, S.L.
Bioorg.Med.Chem.Lett.